Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement
Joint Authors
Du, Wenjing
Zhou, Keyuan
Zeng, Jincheng
Huang, Mingyuan
Liu, Jun
Zhang, Haiyang
Cao, Longbin
Yang, Weiqing
Zhang, Hui
Wang, Zhiyong
Wei, Pei
Wu, Weiquan
Huang, Zhulin
Fang, Ying
Lin, Qiling
Qin, Xingwen
Zhang, Zhizhong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Enterovirus 71 (EV71) is a major pathogen for severe hand, foot, and mouth disease (HFMD), which leads to severe neurological complications and has high morbidity and mortality.
Reliable biomarker for the prediction of deterioration in EV71-infected children with central nervous system (CNS) involvement may reduce the cardiopulmonary failure and mortality.
Here, we found that serum IL-27 levels were significantly higher in stage III EV71-infected HFMD patients with early cardiopulmonary failure and strong correlation with CRP levels.
IL27p28 polymorphisms (rs153109, rs17855750, and rs181206) did not influence IL-27 production, and these three SNPs were not associated with EV71 infection risk and clinical stage.
IL-27 can be used as an prediction indicator for early cardiopulmonary failure in EV71-infected children with CNS involvement.
American Psychological Association (APA)
Huang, Mingyuan& Du, Wenjing& Liu, Jun& Zhang, Haiyang& Cao, Longbin& Yang, Weiqing…[et al.]. 2016. Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111046
Modern Language Association (MLA)
Huang, Mingyuan…[et al.]. Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111046
American Medical Association (AMA)
Huang, Mingyuan& Du, Wenjing& Liu, Jun& Zhang, Haiyang& Cao, Longbin& Yang, Weiqing…[et al.]. Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111046