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The Role of Protein Arginine Methyltransferases in Inflammatory Responses
Joint Authors
Yang, Woo Seok
Kim, Ji Hye
Kim, Eunji
Yoo, Byong Chul
Cho, Jae Youl
Hong, Sungyoul
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Protein arginine methyltransferases (PRMTs) mediate the methylation of a number of protein substrates of arginine residues and serve critical functions in many cellular responses, including cancer development, progression, and aggressiveness, T-lymphocyte activation, and hepatic gluconeogenesis.
There are nine members of the PRMT family, which are divided into 4 types (types I–IV).
Although most PRMTs do not require posttranslational modification (PTM) to be activated, fine-tuning modifications, such as interactions between cofactor proteins, subcellular compartmentalization, and regulation of RNA, via micro-RNAs, seem to be required.
Inflammation is an essential defense reaction of the body to eliminate harmful stimuli, including damaged cells, irritants, or pathogens.
However, chronic inflammation can eventually cause several types of diseases, including some cancers, atherosclerosis, rheumatoid arthritis, and periodontitis.
Therefore, inflammation responses should be well modulated.
In this review, we briefly discuss the role of PRMTs in the control of inflammation.
More specifically, we review the roles of four PRMTs (CARM1, PRMT1, PRMT5, and PRMT6) in modulating inflammation responses, particularly in terms of modulating the transcriptional factors or cofactors related to inflammation.
Based on the regulatory roles known so far, we propose that PRMTs should be considered one of the target molecule groups that modulate inflammatory responses.
American Psychological Association (APA)
Kim, Ji Hye& Yoo, Byong Chul& Yang, Woo Seok& Kim, Eunji& Hong, Sungyoul& Cho, Jae Youl. 2016. The Role of Protein Arginine Methyltransferases in Inflammatory Responses. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111047
Modern Language Association (MLA)
Kim, Ji Hye…[et al.]. The Role of Protein Arginine Methyltransferases in Inflammatory Responses. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111047
American Medical Association (AMA)
Kim, Ji Hye& Yoo, Byong Chul& Yang, Woo Seok& Kim, Eunji& Hong, Sungyoul& Cho, Jae Youl. The Role of Protein Arginine Methyltransferases in Inflammatory Responses. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111047