![](/images/graphics-bg.png)
Multiple Sclerosis and Obesity: Possible Roles of Adipokines
Joint Authors
López-Roa, Rocío Ivette
Rojas-Mayorquín, Argelia E.
Ortuño-Sahagún, Daniel
Carrera-Quintanar, Lucrecia
Guerrero-García, José de Jesús
Márquez-Aguirre, Ana Laura
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-18
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity.
The possible link between MS and obesity has become more interesting in recent years since the discovery of the remarkable properties of adipose tissue.
Once MS is initiated, obesity can contribute to increased disease severity by negatively influencing disease progress and treatment response, but, also, obesity in early life is highly relevant as a susceptibility factor and causally related risk for late MS development.
The aim of this review was to discuss recent evidence about the link between obesity, as a chronic inflammatory state, and the pathogenesis of MS as a chronic autoimmune and inflammatory disease.
First, we describe the main cells involved in MS pathogenesis, both from neural tissue and from the immune system, and including a new participant, the adipocyte, focusing on their roles in MS.
Second, we concentrate on the role of several adipokines that are able to participate in the mediation of the immune response in MS and on the possible cross talk between the latter.
Finally, we explore recent therapy that involves the transplantation of adipocyte precursor cells for the treatment of MS.
American Psychological Association (APA)
Guerrero-García, José de Jesús& Carrera-Quintanar, Lucrecia& López-Roa, Rocío Ivette& Márquez-Aguirre, Ana Laura& Rojas-Mayorquín, Argelia E.& Ortuño-Sahagún, Daniel. 2016. Multiple Sclerosis and Obesity: Possible Roles of Adipokines. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-24.
https://search.emarefa.net/detail/BIM-1111048
Modern Language Association (MLA)
Guerrero-García, José de Jesús…[et al.]. Multiple Sclerosis and Obesity: Possible Roles of Adipokines. Mediators of Inflammation No. 2016 (2016), pp.1-24.
https://search.emarefa.net/detail/BIM-1111048
American Medical Association (AMA)
Guerrero-García, José de Jesús& Carrera-Quintanar, Lucrecia& López-Roa, Rocío Ivette& Márquez-Aguirre, Ana Laura& Rojas-Mayorquín, Argelia E.& Ortuño-Sahagún, Daniel. Multiple Sclerosis and Obesity: Possible Roles of Adipokines. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-24.
https://search.emarefa.net/detail/BIM-1111048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111048