Advantages of Extracellular Ubiquitin in Modulation of Immune Responses
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
T and B lymphocytes play a central role in protecting the human body from infectious pathogens but occasionally they can escape immune tolerance, become activated, and induce autoimmune diseases.
All deregulated cellular processes are associated with improper functioning of the ubiquitin-proteasome system (UPS) in eukaryotic cells.
The role of ubiquitin in regulation of immune responses and in autoimmune diseases is only beginning to emerge.
Ubiquitin is found in intra- and extracellular fluids and is involved in regulation of numerous cellular processes.
Extracellular ubiquitin ascribed a role in lymphocyte differentiation.
It regulates differentiation and maturation of hematopoietic cell lines.
Ubiquitination is involved in initiation, propagation, and termination of immune responses.
Disrupted ubiquitination can lead to autoimmunity.
Recent observations showed that it can suppress immune response and prevent inflammation.
Exogenous ubiquitin may provide good potential as a new tool for targeted therapy for immune mediated disorders of various etiologies.
American Psychological Association (APA)
Sujashvili, Rusudan. 2016. Advantages of Extracellular Ubiquitin in Modulation of Immune Responses. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1111056
Modern Language Association (MLA)
Sujashvili, Rusudan. Advantages of Extracellular Ubiquitin in Modulation of Immune Responses. Mediators of Inflammation No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1111056
American Medical Association (AMA)
Sujashvili, Rusudan. Advantages of Extracellular Ubiquitin in Modulation of Immune Responses. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1111056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111056