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Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury
Joint Authors
Guo, Honglei
Li, Hongmei
Ling, Lilu
Gu, Yong
Ding, Wei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aldosterone (Aldo) is critically involved in the development of renal injury via the production of reactive oxygen species and inflammation.
Endoplasmic reticulum (ER) stress is also evoked in Aldo-induced renal injury.
In the present study, we investigated the role of ER stress in inflammation-mediated renal injury in Aldo-infused mice.
C57BL/6J mice were randomized to receive treatment for 4 weeks as follows: vehicle infusion, Aldo infusion, vehicle infusion plus tauroursodeoxycholic acid (TUDCA), and Aldo infusion plus TUDCA.
The effect of TUDCA on the Aldo-infused inflammatory response and renal injury was investigated using periodic acid-Schiff staining, real-time PCR, Western blot, and ELISA.
We demonstrate that Aldo leads to impaired renal function and inhibition of ER stress via TUDCA attenuates renal fibrosis.
This was indicated by decreased collagen I, collagen IV, fibronectin, and TGF-β expression, as well as the downregulation of the expression of Nlrp3 inflammasome markers, Nlrp3, ASC, IL-1β, and IL-18.
This paper presents an important role for ER stress on the renal inflammatory response to Aldo.
Additionally, the inhibition of ER stress by TUDCA negatively regulates the levels of these inflammatory molecules in the context of Aldo.
American Psychological Association (APA)
Guo, Honglei& Li, Hongmei& Ling, Lilu& Gu, Yong& Ding, Wei. 2016. Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111065
Modern Language Association (MLA)
Guo, Honglei…[et al.]. Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111065
American Medical Association (AMA)
Guo, Honglei& Li, Hongmei& Ling, Lilu& Gu, Yong& Ding, Wei. Endoplasmic Reticulum Chaperon Tauroursodeoxycholic Acid Attenuates Aldosterone-Infused Renal Injury. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111065