Increased IL17A, IFNG, and FOXP3 Transcripts in Moderate-Severe Psoriasis: A Major Influence Exerted by IL17A in Disease Severity
Joint Authors
Pitta, Ivan da Rocha
de Melo Rego, Moacyr Jesus Barreto
Oliveira, Priscilla Stela Santana de
Pereira, Michelly Cristiny
Lima, Emerson Vasconcelos de Andrade
Silva de Paula, Simão Kalebe
Lima, Mariana Modesto de Andrade
Arruda, Rodrigo Gomes de
Oliveira, Wagner Luís Mendes de
Pitta, Maira Galdino da Rocha
Duarte, Ângela Luzia Branco Pinto
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Psoriasis is a chronic and recurrent dermatitis, mediated by keratinocytes and T cells.
Several proinflammatory cytokines contribute to formation and maintenance of psoriatic plaque.
The Th1/Th17 pathways and some of IL-1 family members were involved in psoriasis pathogenesis and could contribute to disease activity.
Therefore, we sought to analyse skin transcript levels of IL17A, IL22, RORC, IL8, IFNG, IL33, IL36A, FOXP3, and IL10 and correlate with clinic of patients with plaque-type psoriasis.
In order to conduct that, we collected punch biopsies from lesional skin and obtained tissue RNA.
After reverse transcription, qRT-PCR quantified the relative mRNA expression.
The main results revealed increased transcripts levels of IL17A, IFNG, and FOXP3 in moderate-severe patients.
Despite this, only IL17A can increase the chance to worsen disease severity.
We also observed many significant positive correlations between each transcript.
In conclusion, IL17A is elevated in lesional skin from psoriasis patients and plays crucial role in disease severity.
American Psychological Association (APA)
Oliveira, Priscilla Stela Santana de& Pereira, Michelly Cristiny& Silva de Paula, Simão Kalebe& Lima, Emerson Vasconcelos de Andrade& Lima, Mariana Modesto de Andrade& Arruda, Rodrigo Gomes de…[et al.]. 2016. Increased IL17A, IFNG, and FOXP3 Transcripts in Moderate-Severe Psoriasis: A Major Influence Exerted by IL17A in Disease Severity. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111067
Modern Language Association (MLA)
Oliveira, Priscilla Stela Santana de…[et al.]. Increased IL17A, IFNG, and FOXP3 Transcripts in Moderate-Severe Psoriasis: A Major Influence Exerted by IL17A in Disease Severity. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111067
American Medical Association (AMA)
Oliveira, Priscilla Stela Santana de& Pereira, Michelly Cristiny& Silva de Paula, Simão Kalebe& Lima, Emerson Vasconcelos de Andrade& Lima, Mariana Modesto de Andrade& Arruda, Rodrigo Gomes de…[et al.]. Increased IL17A, IFNG, and FOXP3 Transcripts in Moderate-Severe Psoriasis: A Major Influence Exerted by IL17A in Disease Severity. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111067
