Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer
Joint Authors
Brady, Nicholas J.
Chuntova, Pavlina
Schwertfeger, Kathryn L.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Macrophages are critical mediators of inflammation and important regulators of developmental processes.
As a key phagocytic cell type, macrophages evolved as part of the innate immune system to engulf and process cell debris and pathogens.
Macrophages produce factors that act directly on their microenvironment and also bridge innate immune responses to the adaptive immune system.
Resident macrophages are important for acting as sensors for tissue damage and maintaining tissue homeostasis.
It is now well-established that macrophages are an integral component of the breast tumor microenvironment, where they contribute to tumor growth and progression, likely through many of the mechanisms that are utilized during normal wound healing responses.
Because macrophages contribute to normal mammary gland development and breast cancer growth and progression, this review will discuss both resident mammary gland macrophages and tumor-associated macrophages with an emphasis on describing how macrophages interact with their surrounding environment during normal development and in the context of cancer.
American Psychological Association (APA)
Brady, Nicholas J.& Chuntova, Pavlina& Schwertfeger, Kathryn L.. 2016. Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111068
Modern Language Association (MLA)
Brady, Nicholas J.…[et al.]. Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111068
American Medical Association (AMA)
Brady, Nicholas J.& Chuntova, Pavlina& Schwertfeger, Kathryn L.. Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111068