Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features
Joint Authors
Lu, Rui
Tan, Ya-Qin
Zhang, Jing
Du, Ge-Fei
Chen, Guan-Ying
Zhou, Gang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oral lichen planus (OLP) is a T cell-mediated inflammatory autoimmune disease.
Autophagy has emerged as a fundamental trafficking event in mediating T cell response, which plays crucial roles in innate and adaptive immunity.
The present study mainly investigated the mRNA expression of autophagy-associated genes in peripheral blood T cells of OLP patients and evaluated correlations between their expression and the clinical features of OLP.
Five differentially expressed autophagy-associated genes were identified by autophagy array.
Quantitative real-time RT-PCR results confirmed that IGF1 expression in the peripheral blood T cells of OLP patients was significantly higher than that in controls, especially in female and middle-aged (30–50 years old) OLP patients.
In addition, ATG9B mRNA levels were significantly lower in nonerosive OLP patients.
However, no significant differences were found in the expression of HGS, ESR1, and SNCA between OLP patients and controls.
Taken together, dysregulation of T cell autophagy may be involved in immune response of OLP and may be correlated with clinical patterns.
American Psychological Association (APA)
Tan, Ya-Qin& Zhang, Jing& Du, Ge-Fei& Lu, Rui& Chen, Guan-Ying& Zhou, Gang. 2016. Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111077
Modern Language Association (MLA)
Tan, Ya-Qin…[et al.]. Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111077
American Medical Association (AMA)
Tan, Ya-Qin& Zhang, Jing& Du, Ge-Fei& Lu, Rui& Chen, Guan-Ying& Zhou, Gang. Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111077