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Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models
Joint Authors
Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
da Matta, Sérgio Luiz Pinto
Sarandy, Mariáurea Matias
Lopes, Fernanda Barbosa
Pinto, Marcus Vinicius Mello
Sartori, Sirlene Souza Rodrigues
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-17
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Background and Purpose.
Skin wound healing is a dynamic process driven by molecular events responsible for the morphofunctional repair of the injured tissue.
In a systematic review, we analyzed the relevance of plant fractions and isolates on skin wound healing.
By revising preclinical investigations with murine models, we investigated if the current evidence could support clinical trials.
Methods.
Studies were selected in the MEDLINE/PubMed and Scopus databases according to the PRISMA statement.
All 32 identified studies were submitted to data extraction and the methodological bias was investigated according to ARRIVE strategy.
Results.
The studies demonstrated that plant fractions and isolates are able to modulate the inflammatory process during skin wound healing, being also effective in attenuating the oxidative tissue damage in the scar tissue and stimulating cell proliferation, neoangiogenesis, collagen synthesis, granulation tissue expansion, reepithelialization, and the wound closure rate.
However, we identified serious methodological flaws in all studies, such as the high level of reporting bias and absence of standardized experimental designs, analytical methods, and outcome measures.
Conclusion.
Considering these limitations, the current evidence generated from flawed methodological animal studies makes it difficult to determine the relevance of herbal medicines to treat skin wounds and derails conducting clinical studies.
American Psychological Association (APA)
Sarandy, Mariáurea Matias& Lopes, Fernanda Barbosa& da Matta, Sérgio Luiz Pinto& Pinto, Marcus Vinicius Mello& Sartori, Sirlene Souza Rodrigues& Novaes, Rômulo Dias…[et al.]. 2016. Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1111079
Modern Language Association (MLA)
Sarandy, Mariáurea Matias…[et al.]. Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models. Mediators of Inflammation No. 2016 (2016), pp.1-25.
https://search.emarefa.net/detail/BIM-1111079
American Medical Association (AMA)
Sarandy, Mariáurea Matias& Lopes, Fernanda Barbosa& da Matta, Sérgio Luiz Pinto& Pinto, Marcus Vinicius Mello& Sartori, Sirlene Souza Rodrigues& Novaes, Rômulo Dias…[et al.]. Effect of Topical Administration of Fractions and Isolated Molecules from Plant Extracts on Skin Wound Healing: A Systematic Review of Murine Experimental Models. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1111079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111079