![](/images/graphics-bg.png)
Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis
Joint Authors
Nomizo, Auro
Sales-Campos, Helioswilton
Cardoso, Cristina Ribeiro Barros
Lazo-Chica, Javier Emilio
Souza, Patrícia Reis de
Basso, Paulo José
Nardini, Viviani
Silva, Angelica
Banquieri, Fernanda
Alves, Vanessa Beatriz Freitas
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The adrenal glands are able to modulate immune responses through neuroimmunoendocrine interactions and cortisol secretion that could suppress exacerbated inflammation such as in inflammatory bowel disease (IBD).
Therefore, here we evaluated the role of these glands in experimental colitis induced by 3% dextran sulfate sodium (DSS) in C57BL/6 mice subjected to adrenalectomy, with or without glucocorticoid (GC) replacement.
Mice succumbed to colitis without adrenals with a higher clinical score and augmented systemic levels of IL-6 and lower LPS.
Furthermore, adrenalectomy negatively modulated systemic regulatory markers.
The absence of adrenals resulted in augmented tolerogenic lamina propria dendritic cells but no compensatory local production of corticosterone and decreased mucosal inflammation associated with increased IFN-γ and FasL in the intestine.
To clarify the importance of GC in this scenario, GC replacement in adrenalectomized mice restored different markers to the same degree of that observed in DSS group.
Finally, this is the first time that adrenal-derived hormones, especially GC, were associated with the differential local modulation of the gut infiltrate, also pointing to a relationship between adrenalectomy and the modulation of systemic regulatory markers.
These findings may elucidate some neuroimmunoendocrine mechanisms that dictate colitis outcome.
American Psychological Association (APA)
Souza, Patrícia Reis de& Sales-Campos, Helioswilton& Basso, Paulo José& Nardini, Viviani& Silva, Angelica& Banquieri, Fernanda…[et al.]. 2016. Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111081
Modern Language Association (MLA)
Souza, Patrícia Reis de…[et al.]. Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111081
American Medical Association (AMA)
Souza, Patrícia Reis de& Sales-Campos, Helioswilton& Basso, Paulo José& Nardini, Viviani& Silva, Angelica& Banquieri, Fernanda…[et al.]. Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111081