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Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools
Joint Authors
Janssen, Edith
Klarquist, Jared
Zhou, Zhenyuan
Shen, Nan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
System lupus erythematosus (SLE) is a multifactorial systemic autoimmune disease with a wide variety of presenting features.
SLE is believed to result from dysregulated immune responses, loss of tolerance of CD4 T cells and B cells to ubiquitous self-antigens, and the subsequent production of anti-nuclear and other autoreactive antibodies.
Recent research has associated lupus development with changes in the dendritic cell (DC) compartment, including altered DC subset frequency and localization, overactivation of mDCs and pDCs, and functional defects in DCs.
Here we discuss the current knowledge on the role of DC dysfunction in SLE pathogenesis, with the focus on DCs as targets for interventional therapies.
American Psychological Association (APA)
Klarquist, Jared& Zhou, Zhenyuan& Shen, Nan& Janssen, Edith. 2016. Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111084
Modern Language Association (MLA)
Klarquist, Jared…[et al.]. Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111084
American Medical Association (AMA)
Klarquist, Jared& Zhou, Zhenyuan& Shen, Nan& Janssen, Edith. Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111084