Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway
Joint Authors
Ren, Xianguo
Bo, Yun
Fan, Junting
Chen, Maosheng
Xu, Daliang
Dong, Yang
He, Haowei
Ren, Xianzhi
Qu, Rong
Jin, Yulian
Zhao, Weihong
Xu, Changliang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice.
The mice were pretreated for 7 days with DAL followed by a single injection of DXR (10 mg/kg) via the tail vein.
Renal function was analyzed 5 weeks after DXR treatment.
DXR caused nephrotoxicity.
The symptoms of nephrotic syndrome were greatly improved after DAL treatment.
The indices of renal fibrosis, the phosphorylation of Smad3, and the expression of alpha-smooth muscle actin (α-SMA), fibronectin, collagen III (Col III), E-cadherin, TGF-β, and Smad7 in response to DXR were all similarly modified by DAL.
The present findings suggest that DAL improved the markers for kidney damage investigated in this model of DXR-induced experimental nephrotoxicity.
American Psychological Association (APA)
Ren, Xianguo& Bo, Yun& Fan, Junting& Chen, Maosheng& Xu, Daliang& Dong, Yang…[et al.]. 2016. Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111089
Modern Language Association (MLA)
Ren, Xianguo…[et al.]. Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111089
American Medical Association (AMA)
Ren, Xianguo& Bo, Yun& Fan, Junting& Chen, Maosheng& Xu, Daliang& Dong, Yang…[et al.]. Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111089
