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Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results
Joint Authors
Dabrowska, Natalia L.
Maciagowska, Marzena
Zolocinska, Aleksandra
Mazur, Slawomir
Siennicka, Katarzyna
Frankowska, Emilia
Kidzinski, Rafał
Chalimoniuk, Małgorzata
Pojda, Zygmunt
Stępień, Adam
Piusińska-Macoch, Renata
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation.
Methods.
The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period.
Results.
At 18 months of follow-up, some patients showed “enticing” improvements on some exploratory efficacy measures, although a significant benefit was not observed for any measure across the entire group.
Neither the progression of disability nor relapses were observed in any cases.
In four patients, we found new gadolinium+ (Gd+) lesions on MRI.
Our results indicate that ASC therapy is safe and does not produce any substantial side effects.
Disease progression-free survival (PFS) of 18 months was seen in all patients with RRMS and SPMS.
In these patients, EDSS scores did not progress above baseline scores.
Gd-enhancing lesions were observed in two cases with RRMS, but these patients did not exhibit changes in EDSS score.
Conclusion.
Intrathecal treatment with ASCs is an attractive form of therapy for patients with MS but should be reserved for cases with aggressive disease progression, for cases that are still in the inflammatory phase, and for the malignant form.
American Psychological Association (APA)
Stępień, Adam& Dabrowska, Natalia L.& Maciagowska, Marzena& Piusińska-Macoch, Renata& Zolocinska, Aleksandra& Mazur, Slawomir…[et al.]. 2016. Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1111094
Modern Language Association (MLA)
Stępień, Adam…[et al.]. Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results. Mediators of Inflammation No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1111094
American Medical Association (AMA)
Stępień, Adam& Dabrowska, Natalia L.& Maciagowska, Marzena& Piusińska-Macoch, Renata& Zolocinska, Aleksandra& Mazur, Slawomir…[et al.]. Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1111094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111094