A Novel Inflammation-Based Stage (I Stage) in Patients with Resectable Esophageal Squamous Cell Carcinoma
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Inflammation plays a key role in cancer.
In the current study, we proposed a novel inflammation-based stage, named I stage, for patients with resectable esophageal squamous cell carcinoma (ESCC).
Methods.
Three hundred and twenty-three patients with resectable ESCC were enrolled in the current study.
The I stage was calculated as follows: patients with high levels of C-reactive protein (CRP) (>10 mg/L), neutrophil-to-lymphocyte ratio (NLR) (>3.5), and platelet-count-to-lymphocyte ratio (PLR) (>150) were defined as I3.
Patients with two, one, or no abnormal value were defined as I2, I1, or I0, respectively.
The prognostic factors were evaluated by univariate and multivariate analyses.
Results.
There were 112 patients for I0, 97 patients for I1, 66 patients for I2, and 48 patients for I3, respectively.
The 5-year cancer-specific survival (CSS) in patients with I0, I1, I2, and I3 was 50.0%, 30.9%, 18.2%, and 8.3%, respectively (I0 versus I1, P = 0.002 ; I1 versus I2, P = 0.012 ; I2 versus I3, P = 0.020 ).
Multivariate analyses revealed that I stage was an independent prognostic factor in patients with resectable ESCC ( P < 0.001 ).
Conclusion.
The inflammation-based stage (I stage) is a novel and useful predictive factor for CSS in patients with resectable ESCC.
American Psychological Association (APA)
Chen, Peng-Cheng& Feng, Ji-Feng. 2016. A Novel Inflammation-Based Stage (I Stage) in Patients with Resectable Esophageal Squamous Cell Carcinoma. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111102
Modern Language Association (MLA)
Chen, Peng-Cheng& Feng, Ji-Feng. A Novel Inflammation-Based Stage (I Stage) in Patients with Resectable Esophageal Squamous Cell Carcinoma. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111102
American Medical Association (AMA)
Chen, Peng-Cheng& Feng, Ji-Feng. A Novel Inflammation-Based Stage (I Stage) in Patients with Resectable Esophageal Squamous Cell Carcinoma. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111102