Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection
Joint Authors
Azzato, F.
Cao, Gabriel
Gómez Llambí, Hernán
Ottaviano, Graciela
Müller, Angélica
Otero-Losada, Matilde
Milei, José
Ambrosio, Giuseppe
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We report experimental evidence confirming renal histopathology, proinflammatory mediators, and oxidative metabolism induced by cola drinking.
Male Wistar rats drank ad libitum regular cola (C, n=12) or tap water (W, n=12).
Measures.
Body weight, nutritional data, plasma glucose, cholesterol fractions, TG, urea, creatinine, coenzyme Q10, SBP, and echocardiograms (0 mo and 6 mo).
At 6 months euthanasia was performed.
Kidneys were processed for histopathology and immunohistochemistry (semiquantitative).
Compared with W, C rats showed (I) overweight (+8%, p<0.05), hyperglycemia (+11%, p<0.05), hypertriglyceridemia (2-fold, p<0.001), higher AIP (2-fold, p<0.01), and lower Q10 level (−55%, p<0.05); (II) increased LV diastolic diameter (+9%, p<0.05) and volume (systolic +24%, p<0.05), posterior wall thinning (−8%, p<0.05), and larger cardiac output (+24%, p<0.05); (III) glomerulosclerosis (+21%, p<0.05), histopathology (+13%, p<0.05), higher tubular expression of IL-6 (7-fold, p<0.001), and TNFα (4-fold, p<0.001).
(IV) Correlations were found for LV dimensions with IL-6 (74%, p<0.001) and TNFα (52%, p<0.001) and fully abolished after TG and Q10 control.
Chronic cola drinking induced cardiac remodeling associated with increase in proinflammatory cytokines and renal damage.
Hypertriglyceridemia and oxidative stress were key factors.
Hypertriglyceridemic lipotoxicity in the context of defective antioxidant/anti-inflammatory protection due to low Q10 level might play a key role in cardiorenal disorder induced by chronic cola drinking in rats.
American Psychological Association (APA)
Otero-Losada, Matilde& Gómez Llambí, Hernán& Ottaviano, Graciela& Cao, Gabriel& Müller, Angélica& Azzato, F.…[et al.]. 2016. Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111110
Modern Language Association (MLA)
Otero-Losada, Matilde…[et al.]. Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111110
American Medical Association (AMA)
Otero-Losada, Matilde& Gómez Llambí, Hernán& Ottaviano, Graciela& Cao, Gabriel& Müller, Angélica& Azzato, F.…[et al.]. Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111110