![](/images/graphics-bg.png)
TLR Signalling Pathways Diverge in Their Ability to Induce PGE2
Joint Authors
Salvi, Valentina
Vaira, Xenia
Gianello, Veronica
Vermi, William
Bugatti, Mattia
Sozzani, Silvano
Bosisio, Daniela
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
PGE2 is a lipid mediator abundantly produced in inflamed tissues that exerts relevant immunoregulatory functions.
Dendritic cells (DCs) are key players in the onset and shaping of the inflammatory and immune responses and, as such, are well known PGE2 targets.
By contrast, the precise role of human DCs in the production of PGE2 is poorly characterized.
Here, we asked whether different ligands of Toll-like receptors (TLRs), a relevant family of pathogen-sensing receptors, could induce PGE2 in human DCs.
The only active ligands were LPS (TLR4 ligand) and R848 (TLR7-8 ligand) although all TLRs, but TLR9, were expressed and functional.
While investigating the molecular mechanisms hindering the release of PGE2, our experiments highlighted so far oversight differences in TLR signalling pathways in terms of MAPK and NF-κB activation.
In addition, we identified that the PGE2-limiting checkpoint downstream TLR3, TLR5, and TLR7 was a defect in COX2 induction, while TLR1/2 and TLR2/6 failed to mobilize arachidonic acid, the substrate for the COX2 enzyme.
Finally, we demonstrated the in vivo expression of PGE2 by myeloid CD11c+ cells, documenting a role for DCs in the production of PGE2 in human inflamed tissues.
American Psychological Association (APA)
Salvi, Valentina& Vaira, Xenia& Gianello, Veronica& Vermi, William& Bugatti, Mattia& Sozzani, Silvano…[et al.]. 2016. TLR Signalling Pathways Diverge in Their Ability to Induce PGE2. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111114
Modern Language Association (MLA)
Salvi, Valentina…[et al.]. TLR Signalling Pathways Diverge in Their Ability to Induce PGE2. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111114
American Medical Association (AMA)
Salvi, Valentina& Vaira, Xenia& Gianello, Veronica& Vermi, William& Bugatti, Mattia& Sozzani, Silvano…[et al.]. TLR Signalling Pathways Diverge in Their Ability to Induce PGE2. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111114