Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in Saudi Arabia
Joint Authors
Morsi, Heba Kamal
Ismail, Manar Mohammad
Gaber, Hassan Abdelaziz Hassan
Elbasmy, Amani Abdelhamid
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Malondialdehyde (MDA) has been implicated in the development of many acute inflammatory, autoimmune diseases as well as chronic inflammatory metabolic disorders.
Involvement of inflammatory response and oxidative stress is currently suggested as a mechanism underlying development of diabetes and its complications.
Objective.
To evaluate the clinical utility of MDA, macrophage migration inhibitory factor (MIF), LDL-C/HDL-C, and TG/HDL-C ratio as noninvasive laboratory markers for prediction of T2DM vascular complications.
Method.
63 Saudi T2DM patients and 16 age and sex matched controls were included.
Serum MDA and MIF were assayed by thiobarbituric acid reactive substances and ELISA, respectively.
TG/HDL-C and LDL-C/HDL-C ratios were calculated.
Results.
Uncontrolled DM patients had significantly higher levels of MDA, MIF, TG/HDL-C, and LDL-C/HDL-C ratios when compared with controlled DM patients and control group ( p < 0.001 ).
MDA had 100% sensitivity and 88% specificity.
MIF showed 97% sensitivity and 100% specificity and LDL-C/HDL-C had 97% sensitivity and 95% specificity.
Meanwhile, TG/HDL-C had the lowest sensitivity and specificity in identifying diabetic patients who would suffer from vascular complications.
Conclusion.
MDA, MIF, and LDL-C/HDL-C could be new predictors of metabolic disturbance which promote vascular complications in T2DM.
American Psychological Association (APA)
Morsi, Heba Kamal& Ismail, Manar Mohammad& Gaber, Hassan Abdelaziz Hassan& Elbasmy, Amani Abdelhamid. 2016. Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in Saudi Arabia. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111121
Modern Language Association (MLA)
Morsi, Heba Kamal…[et al.]. Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in Saudi Arabia. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111121
American Medical Association (AMA)
Morsi, Heba Kamal& Ismail, Manar Mohammad& Gaber, Hassan Abdelaziz Hassan& Elbasmy, Amani Abdelhamid. Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in Saudi Arabia. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111121