Therapeutic Strategies for Neuropathic Pain: Potential Application of Pharmacosynthetics and Optogenetics
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chronic pain originating from neuronal damage remains an incurable symptom debilitating patients.
Proposed molecular modalities in neuropathic pain include ion channel expressions, immune reactions, and inflammatory substrate diffusions.
Recent advances in RNA sequence analysis have discovered specific ion channel expressions in nociceptors such as transient receptor potential (TRP) channels, voltage-gated potassium, and sodium channels.
G protein-coupled receptors (GPCRs) also play an important role in triggering surrounding immune cells.
The multiple protein expressions complicate therapeutic development for neuropathic pain.
Recent progress in optogenetics and pharmacogenetics may herald the development of novel therapeutics for the incurable pain.
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) facilitate the artificial manipulation of intracellular signaling through excitatory or inhibitory G protein subunits activated by biologically inert synthetic ligands.
Expression of excitatory channelrhodopsins and inhibitory halorhodopsins on injured neurons or surrounding cells can attenuate neuropathic pain precisely controlled by light stimulation.
To achieve the discrete treatment of injured neurons, we can exploit the transcriptome database obtained by RNA sequence analysis in specific neuropathies.
This can recommend the suitable promoter information to target the injury sites circumventing intact neurons.
Therefore, novel strategies benefiting from pharmacogenetics, optogenetics, and RNA sequencing might be promising for neuropathic pain treatment in future.
American Psychological Association (APA)
Lee, Gum Hwa& Kim, SangSeong. 2016. Therapeutic Strategies for Neuropathic Pain: Potential Application of Pharmacosynthetics and Optogenetics. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111123
Modern Language Association (MLA)
Lee, Gum Hwa& Kim, SangSeong. Therapeutic Strategies for Neuropathic Pain: Potential Application of Pharmacosynthetics and Optogenetics. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111123
American Medical Association (AMA)
Lee, Gum Hwa& Kim, SangSeong. Therapeutic Strategies for Neuropathic Pain: Potential Application of Pharmacosynthetics and Optogenetics. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111123