Metformin Prevents Fatty Liver and Improves Balance of WhiteBrown Adipose in an Obesity Mouse Model by Inducing FGF21

Joint Authors

Jhun, JooYeon
Byun, Jae-Kyeong
Kim, Eun-Kyung
Cho, Mi-La
Lee, Seon-Yeong
Lee, Seung Hoon
Choi, Jong Young
Jeong, Jeong Hee
Kim, Jae Kyung

Source

Mediators of Inflammation

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-01-19

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases

Abstract EN

Obesity and its associated metabolic disorders are related to the onset of fatty liver and the balance of white adipose tissue (WAT) and brown adipose tissue (BAT).

We hypothesized that metformin, an effective pharmacological treatment for type 2 diabetes, would inhibit white adipogenesis, fatty liver, and metabolic dysfunction.

Metformin was treated daily for 14 weeks in a high-fat dieting C57BL/6J mice.

Serum biomarkers were analyzed and protein level was assessed using confocal staining or flow cytometry.

The development of lipid drops in the liver cells and white adipocyte was measured using hematoxylin and eosin or Oil Red O stains.

Gene expressions were analyzed with quantitative real-time PCR.

Metformin treatment decreased the body weight and improved the metabolic profile of obese mice.

In obese mice, metformin also induced the expression of BAT-related markers and increased fibroblast growth factor (FGF) 21 expression in the liver and in white adipocyte.

Metformin suppressed white adipocyte differentiation via induction of FGF21.

Metformin improves Treg/Th17 balance in CD4+ T cells in mice with high-fat diet-induced obesity.

Metformin also improves glucose metabolism and metabolic disorder.

Interleukin-17 deficiency also decreases inflammation in mice.

Therefore, metformin may be therapeutically useful for the treatment of obesity and metabolic dysfunction.

American Psychological Association (APA)

Kim, Eun-Kyung& Lee, Seung Hoon& Jhun, JooYeon& Byun, Jae-Kyeong& Jeong, Jeong Hee& Lee, Seon-Yeong…[et al.]. 2016. Metformin Prevents Fatty Liver and Improves Balance of WhiteBrown Adipose in an Obesity Mouse Model by Inducing FGF21. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111124

Modern Language Association (MLA)

Kim, Eun-Kyung…[et al.]. Metformin Prevents Fatty Liver and Improves Balance of WhiteBrown Adipose in an Obesity Mouse Model by Inducing FGF21. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111124

American Medical Association (AMA)

Kim, Eun-Kyung& Lee, Seung Hoon& Jhun, JooYeon& Byun, Jae-Kyeong& Jeong, Jeong Hee& Lee, Seon-Yeong…[et al.]. Metformin Prevents Fatty Liver and Improves Balance of WhiteBrown Adipose in an Obesity Mouse Model by Inducing FGF21. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111124

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1111124