Metformin Prevents Fatty Liver and Improves Balance of WhiteBrown Adipose in an Obesity Mouse Model by Inducing FGF21
Joint Authors
Jhun, JooYeon
Byun, Jae-Kyeong
Kim, Eun-Kyung
Cho, Mi-La
Lee, Seon-Yeong
Lee, Seung Hoon
Choi, Jong Young
Jeong, Jeong Hee
Kim, Jae Kyung
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obesity and its associated metabolic disorders are related to the onset of fatty liver and the balance of white adipose tissue (WAT) and brown adipose tissue (BAT).
We hypothesized that metformin, an effective pharmacological treatment for type 2 diabetes, would inhibit white adipogenesis, fatty liver, and metabolic dysfunction.
Metformin was treated daily for 14 weeks in a high-fat dieting C57BL/6J mice.
Serum biomarkers were analyzed and protein level was assessed using confocal staining or flow cytometry.
The development of lipid drops in the liver cells and white adipocyte was measured using hematoxylin and eosin or Oil Red O stains.
Gene expressions were analyzed with quantitative real-time PCR.
Metformin treatment decreased the body weight and improved the metabolic profile of obese mice.
In obese mice, metformin also induced the expression of BAT-related markers and increased fibroblast growth factor (FGF) 21 expression in the liver and in white adipocyte.
Metformin suppressed white adipocyte differentiation via induction of FGF21.
Metformin improves Treg/Th17 balance in CD4+ T cells in mice with high-fat diet-induced obesity.
Metformin also improves glucose metabolism and metabolic disorder.
Interleukin-17 deficiency also decreases inflammation in mice.
Therefore, metformin may be therapeutically useful for the treatment of obesity and metabolic dysfunction.
American Psychological Association (APA)
Kim, Eun-Kyung& Lee, Seung Hoon& Jhun, JooYeon& Byun, Jae-Kyeong& Jeong, Jeong Hee& Lee, Seon-Yeong…[et al.]. 2016. Metformin Prevents Fatty Liver and Improves Balance of WhiteBrown Adipose in an Obesity Mouse Model by Inducing FGF21. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111124
Modern Language Association (MLA)
Kim, Eun-Kyung…[et al.]. Metformin Prevents Fatty Liver and Improves Balance of WhiteBrown Adipose in an Obesity Mouse Model by Inducing FGF21. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111124
American Medical Association (AMA)
Kim, Eun-Kyung& Lee, Seung Hoon& Jhun, JooYeon& Byun, Jae-Kyeong& Jeong, Jeong Hee& Lee, Seon-Yeong…[et al.]. Metformin Prevents Fatty Liver and Improves Balance of WhiteBrown Adipose in an Obesity Mouse Model by Inducing FGF21. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111124