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Protective Effect of Galectin-1 during Histoplasma capsulatum Infection Is Associated with Prostaglandin E2 and Nitric Oxide Modulation
Joint Authors
Stowell, Sean R.
Dejani, Naiara N.
Medeiros, Alexandra I.
Prado, Morgana Kelly Borges
Rodrigues, Lílian Cataldi
Cummings, Richard D.
Dias-Baruffi, Marcelo
Artério Sorgi, Carlos
Faccioli, Lúcia Helena
Ramos, Simone Gusmão
Secatto, Adriana
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Histoplasma capsulatum is a dimorphic fungus that develops a yeast-like morphology in host’s tissue, responsible for the pulmonary disease histoplasmosis.
The recent increase in the incidence of histoplasmosis in immunocompromised patients highlights the need of understanding immunological controls of fungal infections.
Here, we describe our discovery of the role of endogenous galectin-1 (Gal-1) in the immune pathophysiology of experimental histoplasmosis.
All infected wild-type (WT) mice survived while only 1/3 of Lgals1−/− mice genetically deficient in Gal-1 survived 30 days after infection.
Although infected Lgals1−/− mice had increased proinflammatory cytokines, nitric oxide (NO), and elevations in neutrophil pulmonary infiltration, they presented higher fungal load in lungs and spleen.
Infected lung and infected macrophages from Lgals1−/− mice exhibited elevated levels of prostaglandin E2 (PGE2, a prostanoid regulator of macrophage activation) and prostaglandin E synthase 2 (Ptgs2) mRNA.
Gal-1 did not bind to cell surface of yeast phase of H.
capsulatum, in vitro, suggesting that Gal-1 contributed to phagocytes response to infection rather than directly killing the yeast.
The data provides the first demonstration of endogenous Gal-1 in the protective immune response against H.
capsulatum associated with NO and PGE2 as an important lipid mediator in the pathogenesis of histoplasmosis.
American Psychological Association (APA)
Rodrigues, Lílian Cataldi& Secatto, Adriana& Artério Sorgi, Carlos& Dejani, Naiara N.& Medeiros, Alexandra I.& Prado, Morgana Kelly Borges…[et al.]. 2016. Protective Effect of Galectin-1 during Histoplasma capsulatum Infection Is Associated with Prostaglandin E2 and Nitric Oxide Modulation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111125
Modern Language Association (MLA)
Rodrigues, Lílian Cataldi…[et al.]. Protective Effect of Galectin-1 during Histoplasma capsulatum Infection Is Associated with Prostaglandin E2 and Nitric Oxide Modulation. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111125
American Medical Association (AMA)
Rodrigues, Lílian Cataldi& Secatto, Adriana& Artério Sorgi, Carlos& Dejani, Naiara N.& Medeiros, Alexandra I.& Prado, Morgana Kelly Borges…[et al.]. Protective Effect of Galectin-1 during Histoplasma capsulatum Infection Is Associated with Prostaglandin E2 and Nitric Oxide Modulation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111125