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Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-11
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
Abundant evidence indicates that cannabinoids modulate immune responses.
An inflammatory response is triggered when innate immune cells receive a danger signal provided by pathogen- or damage-associated molecular patterns engaging pattern-recognition receptors.
Toll-like receptor family members are prominent pattern-recognition receptors expressed on innate immune cells.
Cannabinoids suppress Toll-like receptor-mediated inflammatory responses.
However, the relationship between the endocannabinoid system and innate immune system may not be one-sided.
Innate immune cells express cannabinoid receptors and produce endogenous cannabinoids.
Hence, innate immune cells may play a role in regulating endocannabinoid homeostasis, and, in turn, the endocannabinoid system modulates local inflammatory responses.
Studies designed to probe the interaction between the innate immune system and the endocannabinoid system may identify new potential molecular targets in developing therapeutic strategies for chronic inflammatory diseases.
This review discusses the endocannabinoid system and Toll-like receptor family and evaluates the interaction between them.
American Psychological Association (APA)
McCoy, Kathleen L.. 2016. Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1111128
Modern Language Association (MLA)
McCoy, Kathleen L.. Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation. Mediators of Inflammation No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1111128
American Medical Association (AMA)
McCoy, Kathleen L.. Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1111128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111128