Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial
Joint Authors
Chen, Hui
Liu, Shuai
Ji, Lu
Wu, Tianfeng
Ji, Yong
Zhou, Yuying
Zheng, Miaoyan
Zhang, Meilin
Xu, Weili
Huang, Guowei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background/Aims.
Low serum folate levels can alter inflammatory reactions.
Both phenomena have been linked to Alzheimer’s disease (AD), but the effect of folic acid on AD itself is unclear.
We quantified folate supplementation’s effect on inflammation and cognitive function in patients with AD over the course of 6 months.
Methods.
Patients newly diagnosed with AD (age > 60 years; n = 121 ; mild to severe; international criteria) and being treated with donepezil were randomly assigned into two groups with (intervention group) or without (control group) supplemental treatment with folic acid (1.25 mg/d) for 6 months.
The Mini-Mental State Examination (MMSE) was administered to all patients at baseline and follow-up, and blood samples were taken before and after treatment.
We quantified serum folate, amyloid beta (Aβ), interleukin-6 (IL-6), tumor necrosis factor α (TNFα), plasma homocysteine (Hcy), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and the mRNA levels of presenilin (PS), IL-6, and TNFα in leukocytes.
Data were analyzed using a repeated-measures mixed model.
Results.
The mean MMSE was slightly increased in the intervention group compared to that in the control group ( P < 0.05 ).
Posttreatment, plasma SAM and SAM/SAH levels were significantly higher ( P < 0.05 ), while Aβ 40, PS1-mRNA, and TNFα-mRNA levels were lower in the intervention group than in the control group ( P < 0.05 ).
The Aβ 42/Aβ 40 ratio was also higher in the intervention group ( P < 0.05 ).
Conclusions.
Folic acid is beneficial in patients with AD.
Inflammation may play an important role in the interaction between folic acid and AD.
This trial is registered with clinical trial registration number ChiCTR-TRC-13003246.
American Psychological Association (APA)
Chen, Hui& Liu, Shuai& Ji, Lu& Wu, Tianfeng& Ji, Yong& Zhou, Yuying…[et al.]. 2016. Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111132
Modern Language Association (MLA)
Chen, Hui…[et al.]. Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111132
American Medical Association (AMA)
Chen, Hui& Liu, Shuai& Ji, Lu& Wu, Tianfeng& Ji, Yong& Zhou, Yuying…[et al.]. Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111132