Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis
Joint Authors
Zajkowska, Monika
Głażewska, Edyta Katarzyna
Będkowska, Grażyna Ewa
Chorąży, Przemysław
Szmitkowski, Maciej
Ławicki, Sławomir
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Breast cancer (BC) is the most common malignancy in women.
Vascular endothelial growth factor (VEGF) has been described as an important regulator of angiogenesis which plays a vital role in the progression of tumor.
Macrophage colony-stimulating factor (M-CSF) is a cytokine whose functions include regulation of hematopoietic lineages cells growth, proliferation, and differentiation.
We investigated the diagnostic significance of these parameters in comparison to CA15-3 in BC patients and in relation to the control group (benign breast tumor and healthy women).
Plasma levels of the tested parameters were determined by ELISA and CA15-3 was determined by CMIA.
VEGF was shown to be comparable to CA15-3 values of sensitivity in BC group and, what is more important, higher values in early stages of BC.
VEGF was also the only parameter which has statistically significant AUC in all stages of cancer.
M-CSF has been shown to be comparable to CA15-3 and VEGF, specificity, and AUC values only in stages III and IV of BC.
These results indicate the usefulness and high diagnostic power of VEGF in the detection of BC.
Also, it occurred to be the best candidate for cancer diagnostics in stages I and II of BC and in the differentiation between BC and benign cases.
American Psychological Association (APA)
Zajkowska, Monika& Głażewska, Edyta Katarzyna& Będkowska, Grażyna Ewa& Chorąży, Przemysław& Szmitkowski, Maciej& Ławicki, Sławomir. 2016. Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111134
Modern Language Association (MLA)
Zajkowska, Monika…[et al.]. Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111134
American Medical Association (AMA)
Zajkowska, Monika& Głażewska, Edyta Katarzyna& Będkowska, Grażyna Ewa& Chorąży, Przemysław& Szmitkowski, Maciej& Ławicki, Sławomir. Diagnostic Power of Vascular Endothelial Growth Factor and Macrophage Colony-Stimulating Factor in Breast Cancer Patients Based on ROC Analysis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111134