Association of Serum Adropin Concentrations with Diabetic Nephropathy
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Adropin is a newly identified regulatory protein encoded by the Enho gene and is critically involved in energy homeostasis and insulin sensitivity.
This study aims to determine the correlation of serum adropin concentrations with diabetic nephropathy (DN).
Methods.
This study consisted of 245 patients with type 2 diabetes mellitus (T2DM) and 81 healthy subjects.
Then T2DM patients were divided into normoalbuminuria, microalbuminuria, and macroalbuminuria subgroups based on urine albumin to creatinine ratio (ACR).
Results.
T2DM patients showed significantly lower serum adropin concentrations than those in the controls.
T2DM patients with macroalbuminuria had significantly decreased serum adropin concentrations compared with the other three groups.
In addition, T2DM patients with microalbuminuria showed lower serum adropin concentrations than those in patients with normoalbuminuria.
Logistic regression analysis showed that serum adropin was correlated with decreased risk of developing T2DM and DN.
Pearson correlation analysis indicated that serum adropin was negatively correlated with body mass index (BMI), blood urea nitrogen, creatinine, and ACR and positively correlated with glomerular filtration rate.
Furthermore, multiple linear regression analysis showed that BMI and ACR were negatively correlated with serum adropin levels.
Conclusion.
Serum adropin concentrations are negatively associated with renal function.
Adropin may be implicated in the pathogenesis of DN development.
American Psychological Association (APA)
Hu, Wenchao& Chen, Li. 2016. Association of Serum Adropin Concentrations with Diabetic Nephropathy. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1111137
Modern Language Association (MLA)
Hu, Wenchao& Chen, Li. Association of Serum Adropin Concentrations with Diabetic Nephropathy. Mediators of Inflammation No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1111137
American Medical Association (AMA)
Hu, Wenchao& Chen, Li. Association of Serum Adropin Concentrations with Diabetic Nephropathy. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1111137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111137