Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line
Joint Authors
Ma, Jin Yeul
Park, Kwang-Il
Lee, Bo Hyoung
Kim, Dong-Gun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) comprises Crohn’s disease (CD) and ulcerative colitis (UC).
IBD increases the risk of colorectal cancer (CRC), depending on the extent and duration of intestinal inflammation.
Increased IL-6 expression has been reported in IBD patients, which may be associated with intestinal barrier function through discontinuous tight junction (TJ).
KIOM-MA is a specific agent for allergic diseases and cancer, and it is composed of several plants; these herbs have been used in traditional oriental medicine.
We fermented KIOM-MA, the product of KIOM-MA128, using probiotics to improve the therapeutic efficacy via the absorption and bioavailability of the active ingredients.
In this study, we demonstrated that KIOM-MA/MA128 exhibited anticolitis effects via the modulation of TJ protein.
Interleukin-6 resulted in a dose-dependent decrease in the TER and an increase in the FITC-dextran permeability; however, pretreatment with 400 µg/ml KIOM-MA/MA128 resulted in a significant increase in the TER and a decrease in the FITC-dextran permeability via IL-6 induction.
Furthermore, protein and mRNA TJ levels remained stable after pretreatment with 400 µg/ml KIOM-MA/MA128.
Moreover, KIOM-MA/MA128 suppressed the expression of PLCγ1 and PKC.
Taken together, these findings suggest novel information and clue of the anticolitis effects of KIOM-MA128 via regulation of tight junction.
American Psychological Association (APA)
Park, Kwang-Il& Kim, Dong-Gun& Lee, Bo Hyoung& Ma, Jin Yeul. 2016. Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111146
Modern Language Association (MLA)
Park, Kwang-Il…[et al.]. Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line. Mediators of Inflammation No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1111146
American Medical Association (AMA)
Park, Kwang-Il& Kim, Dong-Gun& Lee, Bo Hyoung& Ma, Jin Yeul. Fermented Herbal Formulas KIOM-MA128 Ameliorate IL-6-Induced Intestinal Barrier Dysfunction in Colon Cancer Cell Line. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1111146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111146