Balancing Inflammation: The Link between Th17 and Regulatory T Cells
Joint Authors
Diller, Maggie L.
Kudchadkar, Ragini R.
Delman, Keith A.
Ford, Mandy L.
Lawson, David H.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
CD4+ T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics.
IL-17-producing CD4+ T cells (Th17 cells) represent a distinct subset of the CD4+ T cell lineage.
Recent evidence suggests that Th17 cells carry out effector functions similar to cytotoxic CD8+ T cells and play an important role in the clearance of extracellular pathogens and fungi.
Th17 cell differentiation and function are closely related to the development and function of regulatory T cells ( T R E G ) .
The balance between these two cell populations is essential for immune homeostasis and dysregulation of this balance has been implicated in a variety of inflammatory conditions including autoimmunity, allograft rejection, and tumorigenesis.
Emerging evidence reports a significant amount of plasticity between the Th17 and regulatory T cell compartments, and the mechanisms by which these cells communicate and influence each other are just beginning to be understood.
In this review, we highlight recent findings detailing the mechanisms driving Th17 and T R E G plasticity and discuss the biologic consequences of their unique relationship.
American Psychological Association (APA)
Diller, Maggie L.& Kudchadkar, Ragini R.& Delman, Keith A.& Lawson, David H.& Ford, Mandy L.. 2016. Balancing Inflammation: The Link between Th17 and Regulatory T Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111150
Modern Language Association (MLA)
Diller, Maggie L.…[et al.]. Balancing Inflammation: The Link between Th17 and Regulatory T Cells. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111150
American Medical Association (AMA)
Diller, Maggie L.& Kudchadkar, Ragini R.& Delman, Keith A.& Lawson, David H.& Ford, Mandy L.. Balancing Inflammation: The Link between Th17 and Regulatory T Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111150