Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters
Joint Authors
Deng, Huacong
Qu, Hua
Luo, Yuanyuan
Wang, Hang
Wei, Huili
Wu, Jing
Duan, Yang
Liu, Dan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM).
Plasma periostin levels in the T2DM group were significantly higher than the NGT group (P<0.01).
Patients with both OB and T2DM had the highest periostin levels.
Correlation analysis showed that plasma periostin levels were positively correlated with weight, waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), fasting plasma glucose (FPG), 2 h postchallenge plasma glucose (2 h PG), glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), TNF-α, and IL-6 (P<0.05 or 0.001) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) (P<0.001).
Multiple linear regression analysis showed that TG, TNF-α, and HOMA-IR were independent related factors in influencing the levels of plasma periostin (P<0.001).
These results suggested that Chinese patients with obesity and T2DM had significantly higher plasma periostin levels.
Plasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance.
American Psychological Association (APA)
Luo, Yuanyuan& Qu, Hua& Wang, Hang& Wei, Huili& Wu, Jing& Duan, Yang…[et al.]. 2016. Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1111153
Modern Language Association (MLA)
Luo, Yuanyuan…[et al.]. Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters. Mediators of Inflammation No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1111153
American Medical Association (AMA)
Luo, Yuanyuan& Qu, Hua& Wang, Hang& Wei, Huili& Wu, Jing& Duan, Yang…[et al.]. Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1111153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111153