Linking CD11b+ Dendritic Cells and Natural Killer T Cells to Plaque Inflammation in Atherosclerosis
Joint Authors
Schrijvers, Dorien
De Winter, Benedicte
Rombouts, Miche
Ammi, Rachid
Van Brussel, Ilse
Roth, Lynn
Vercauteren, Sven R.
Hendriks, Jeroen M. H.
Lauwers, Patrick
Van Schil, Paul E.
De Meyer, Guido R. Y.
Fransen, Erik
Cools, Nathalie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Atherosclerosis remains the leading cause of death and disability in our Western society.
To investigate whether the dynamics of leukocyte (sub)populations could be predictive for plaque inflammation during atherosclerosis, we analyzed innate and adaptive immune cell distributions in blood, plaques, and lymphoid tissue reservoirs in apolipoprotein E-deficient (ApoE−/−) mice and in blood and plaques from patients undergoing endarterectomy.
Firstly, there was predominance of the CD11b+ conventional dendritic cell (cDC) subset in the plaque.
Secondly, a strong inverse correlation was observed between CD11b+ cDC or natural killer T (NKT) cells in blood and markers of inflammation in the plaque (including CD3, T-bet, CCR5, and CCR7).
This indicates that circulating CD11b+ cDC and NKT cells show great potential to reflect the inflammatory status in the atherosclerotic plaque.
Our results suggest that distinct changes in inflammatory cell dynamics may carry biomarker potential reflecting atherosclerotic lesion progression.
This not only is crucial for a better understanding of the immunopathogenesis but also bares therapeutic potential, since immune cell-based therapies are emerging as a promising novel strategy in the battle against atherosclerosis and its associated comorbidities.
The cDC-NKT cell interaction in atherosclerosis serves as a good candidate for future investigations.
American Psychological Association (APA)
Rombouts, Miche& Ammi, Rachid& Van Brussel, Ilse& Roth, Lynn& De Winter, Benedicte& Vercauteren, Sven R.…[et al.]. 2016. Linking CD11b+ Dendritic Cells and Natural Killer T Cells to Plaque Inflammation in Atherosclerosis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111157
Modern Language Association (MLA)
Rombouts, Miche…[et al.]. Linking CD11b+ Dendritic Cells and Natural Killer T Cells to Plaque Inflammation in Atherosclerosis. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111157
American Medical Association (AMA)
Rombouts, Miche& Ammi, Rachid& Van Brussel, Ilse& Roth, Lynn& De Winter, Benedicte& Vercauteren, Sven R.…[et al.]. Linking CD11b+ Dendritic Cells and Natural Killer T Cells to Plaque Inflammation in Atherosclerosis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111157