Dyslipidemia and Diabetes Increase the OPGTRAIL Ratio in the Cardiovascular System
Joint Authors
Fabris, Bruno
Toffoli, Barbara
Bernardi, Stella
Bartelloni, Giacomo
Bossi, Fleur
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Dyslipidemia and diabetes are two of the most well established risk factors for the development of cardiovascular disease (CVD).
Both of them usually activate a complex range of pathogenic pathways leading to organ damage.
Here we hypothesized that dyslipidemia and diabetes could affect osteoprotegerin (OPG) and TNF-related apoptosis-inducing ligand (TRAIL) expression in the vessels and the heart.
Materials and Methods.
Gene and protein expression of OPG, TRAIL, and OPG/TRAIL ratio were quantified in the aorta and the hearts of control mice, dyslipidemic mice, and diabetic mice.
Results.
Diabetes significantly increased OPG and the OPG/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG and reduced TRAIL expression, thus increasing cardiac OPG/TRAIL ratio.
Conclusions.
This work shows that both dyslipidemia and diabetes affect OPG/TRAIL ratio in the cardiovascular system.
This could contribute to the changes in circulating OPG/TRAIL which are observed in patients with diabetes and CVD.
Most importantly, these changes could mediate/contribute to atherosclerosis development and cardiac remodeling.
American Psychological Association (APA)
Toffoli, Barbara& Fabris, Bruno& Bartelloni, Giacomo& Bossi, Fleur& Bernardi, Stella. 2016. Dyslipidemia and Diabetes Increase the OPGTRAIL Ratio in the Cardiovascular System. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111159
Modern Language Association (MLA)
Toffoli, Barbara…[et al.]. Dyslipidemia and Diabetes Increase the OPGTRAIL Ratio in the Cardiovascular System. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1111159
American Medical Association (AMA)
Toffoli, Barbara& Fabris, Bruno& Bartelloni, Giacomo& Bossi, Fleur& Bernardi, Stella. Dyslipidemia and Diabetes Increase the OPGTRAIL Ratio in the Cardiovascular System. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111159