![](/images/graphics-bg.png)
Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation
Joint Authors
Iqbal, Asif Jilani
Kapellos, Theodore S.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Macrophages function as sentinel cells, which constantly monitor the host environment for infection or injury.
Macrophages have been shown to exhibit a spectrum of activated phenotypes, which can often be categorised under the M1/M2 paradigm.
M1 macrophages secrete proinflammatory cytokines and chemokines, such as TNF-α, IL-6, IL-12, CCL4, and CXCL10, and induce phagocytosis and oxidative dependent killing mechanisms.
In contrast, M2 macrophages support wound healing and resolution of inflammation.
In the past decade, interest has grown in understanding the mechanisms involved in regulating macrophage activation.
In particular, epigenetic control of M1 or M2 activation states has been shown to rely on posttranslational modifications of histone proteins adjacent to inflammatory-related genes.
Changes in methylation and acetylation of histones by methyltransferases, demethylases, acetyltransferases, and deacetylases can all impact how macrophage phenotypes are generated.
In this review, we summarise the latest advances in the field of epigenetic regulation of macrophage polarisation to M1 or M2 states, with particular focus on the cytokine and chemokine profiles associated with these phenotypes.
American Psychological Association (APA)
Kapellos, Theodore S.& Iqbal, Asif Jilani. 2016. Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1111161
Modern Language Association (MLA)
Kapellos, Theodore S.& Iqbal, Asif Jilani. Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation. Mediators of Inflammation No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1111161
American Medical Association (AMA)
Kapellos, Theodore S.& Iqbal, Asif Jilani. Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1111161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111161