Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis
Joint Authors
Segura-Cervantes, Enrique
Mancilla-Ramírez, Javier
González-Canudas, Jorge
Alba, Erika
Santillán-Ballesteros, René
Morales-Barquet, Deneb
Sandoval-Plata, Gabriela
Galindo-Sevilla, Norma
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The response of the adaptive immune system is usually less intense in premature neonates than term neonates.
The primary objective of this study was to determine whether immunological parameters vary between preterm (PT) neonates (≥32 weeks of gestational age) and very preterm (VPT) neonates (<32 weeks of gestational age).
A cross-sectional study was designed to prospectively follow PT and VPT neonates at risk of developing sepsis.
Plasma concentrations of IFN-γ, TNF-α, IL-6, IL-4, and IL-10 were detected using flow cytometry.
C-reactive protein (C-RP) and the complex SC5b-9 were detected in the plasma using commercial kits.
A total of 83 patients were included.
The laboratory results and clinical histories showed that 26 patients had sepsis; 14 were VPT, and 12 were PT.
The levels of C-RP, SC5b-9 (innate immune response mediators), and IL-10 or IL-4 (anti-inflammatory cytokines) were elevated during sepsis in both groups.
IFN-γ, TNF-α, and IL-6 (proinflammatory cytokines) were differentially elevated only in PT neonates.
The VPT neonates with sepsis presented increases in C-RP, SC5b-9, and anti-inflammatory cytokines but not in proinflammatory cytokines, whereas PT neonates showed increases in all studied mediators of inflammation.
American Psychological Association (APA)
Segura-Cervantes, Enrique& Mancilla-Ramírez, Javier& González-Canudas, Jorge& Alba, Erika& Santillán-Ballesteros, René& Morales-Barquet, Deneb…[et al.]. 2016. Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111162
Modern Language Association (MLA)
Segura-Cervantes, Enrique…[et al.]. Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111162
American Medical Association (AMA)
Segura-Cervantes, Enrique& Mancilla-Ramírez, Javier& González-Canudas, Jorge& Alba, Erika& Santillán-Ballesteros, René& Morales-Barquet, Deneb…[et al.]. Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111162