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Thyroid Hormones, Oxidative Stress, and Inflammation
Joint Authors
Di Segni, C.
Raimondo, Sebastiano
Olivieri, Giulio
Meucci, Elisabetta
Currò, Diego
Silvestrini, Andrea
Mancini, Antonio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Inflammation and oxidative stress (OS) are closely related processes, as well exemplified in obesity and cardiovascular diseases.
OS is also related to hormonal derangement in a reciprocal way.
Among the various hormonal influences that operate on the antioxidant balance, thyroid hormones play particularly important roles, since both hyperthyroidism and hypothyroidism have been shown to be associated with OS in animals and humans.
In this context, the nonthyroidal illness syndrome (NTIS) that typically manifests as reduced conversion of thyroxine (T4) to triiodothyronine (T3) in different acute and chronic systemic conditions is still a debated topic.
The pathophysiological mechanisms of this syndrome are reviewed, together with the roles of deiodinases, the enzymes responsible for the conversion of T4 to T3, in both physiological and pathological situations.
The presence of OS indexes in NTIS supports the hypothesis that it represents a condition of hypothyroidism at the tissue level and not only an adaptive mechanism to diseases.
American Psychological Association (APA)
Mancini, Antonio& Di Segni, C.& Raimondo, Sebastiano& Olivieri, Giulio& Silvestrini, Andrea& Meucci, Elisabetta…[et al.]. 2016. Thyroid Hormones, Oxidative Stress, and Inflammation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111165
Modern Language Association (MLA)
Mancini, Antonio…[et al.]. Thyroid Hormones, Oxidative Stress, and Inflammation. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111165
American Medical Association (AMA)
Mancini, Antonio& Di Segni, C.& Raimondo, Sebastiano& Olivieri, Giulio& Silvestrini, Andrea& Meucci, Elisabetta…[et al.]. Thyroid Hormones, Oxidative Stress, and Inflammation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111165