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Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis
Joint Authors
Yang, XueZhi
Chang, Yan
Wei, Wei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammation, as a feature of rheumatoid arthritis (RA), leads to the activation of endothelial cells (ECs).
Activated ECs induce atherosclerosis through an increased expression of leukocyte adhesion molecules.
Endothelial dysfunction (ED) is recognized as a failure of endothelial repair mechanisms.
It is also an early preclinical marker of atherosclerosis and is commonly found in RA patients.
RA is now established as an independent cardiovascular risk factor, while mechanistic determinants of ED in RA are still poorly understood.
An expanding body of study has shown that EC at a site of RA is both active participant and regulator of inflammatory process.
Over the last decade, a role for endothelial dysfunction in RA associated with cardiovascular disease (CVD) has been hypothesized.
At the same time, several maintenance drugs targeting this phenomenon have been tested, which has promising results.
Assessment of endothelial function may be a useful tool to identify and monitor RA patients.
American Psychological Association (APA)
Yang, XueZhi& Chang, Yan& Wei, Wei. 2016. Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111169
Modern Language Association (MLA)
Yang, XueZhi…[et al.]. Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111169
American Medical Association (AMA)
Yang, XueZhi& Chang, Yan& Wei, Wei. Endothelial Dysfunction and Inflammation: Immunity in Rheumatoid Arthritis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111169