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Elevated Expression of Programmed Death-1 and Programmed Death Ligand-1 Negatively Regulates Immune Response against Cervical Cancer Cells
Joint Authors
Ding, Jianbing
Pang, Nannan
Chen, Zhifang
Du, Rong
Zhu, Yuejie
Fan, Lingling
Cai, Donghui
Ding, Yan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The present study is to measure the expression of programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), as well as its clinical significance in cervical cancer patients.
Our results showed that different T cell subsets in patients with cervical cancer had high expression of PD-1, and DCs had high expression of PD-L1.
High expression of PD-1 on Treg cells in cervical cancer patients facilitated the production of TGF-β and IL-10 but inhibited the production of IFN-γ.
Cervical cancer elevated the expression of PD-1 and PD-L1 in mRNA level.
PD-1 expression in peripheral blood of cervical cancer patients was related with tumor differentiation, lymph node metastasis, and invasiveness.
PD-1/PD-L1 pathway inhibited lymphocyte proliferation but enhanced the secretion of IL-10 and TGF-β in vitro.
In summary, our findings demonstrate that elevated levels of PD-1/PD-L1, TGF-β, and IL-10 in peripheral blood of cervical cancer patients may negatively regulate immune response against cervical cancer cells and contribute to the progression of cervical cancer.
Therefore, PD-1/PD-L1 pathway may become an immunotherapy target in the future.
American Psychological Association (APA)
Chen, Zhifang& Pang, Nannan& Du, Rong& Zhu, Yuejie& Fan, Lingling& Cai, Donghui…[et al.]. 2016. Elevated Expression of Programmed Death-1 and Programmed Death Ligand-1 Negatively Regulates Immune Response against Cervical Cancer Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111171
Modern Language Association (MLA)
Chen, Zhifang…[et al.]. Elevated Expression of Programmed Death-1 and Programmed Death Ligand-1 Negatively Regulates Immune Response against Cervical Cancer Cells. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111171
American Medical Association (AMA)
Chen, Zhifang& Pang, Nannan& Du, Rong& Zhu, Yuejie& Fan, Lingling& Cai, Donghui…[et al.]. Elevated Expression of Programmed Death-1 and Programmed Death Ligand-1 Negatively Regulates Immune Response against Cervical Cancer Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111171