The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation
Joint Authors
Molteni, Monica
Gemma, Sabrina
Rossetti, Carlo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs).
They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections.
TLR4 has been long recognized as the sensing receptor for gram-negative lipopolysaccharide (LPS).
In addition, it also binds endogenous molecules produced as a result of tissue injury.
Hence, TLR4 represents a key receptor on which both infectious and noninfectious stimuli converge to induce a proinflammatory response.
TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is also involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response.
This review focuses on the research progress about the role of TLR4 activation in infectious and noninfectious (e.g., sterile) inflammation and the effects of TLR4 signaling in some pathological conditions.
American Psychological Association (APA)
Molteni, Monica& Gemma, Sabrina& Rossetti, Carlo. 2016. The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111184
Modern Language Association (MLA)
Molteni, Monica…[et al.]. The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111184
American Medical Association (AMA)
Molteni, Monica& Gemma, Sabrina& Rossetti, Carlo. The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111184