Differential Expression of Inflammation-Related Genes in Children with Down Syndrome
Joint Authors
Goloni-Bertollo, Eny Maria
Silva, Cláudia Regina Santos
Biselli-Périco, Joice Matos
Zampieri, Bruna Lancia
Silva, Wilson Araujo
de Souza, Jorge Estefano Santana
Bürger, Matheus Carvalho
Pavarino, Érika Cristina
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The aim of the study was to investigate the expression patterns of a specific set of genes involved in the inflammation process in children with Down Syndrome (DS) and children without the syndrome (control group) to identify differences that may be related to the immune abnormalities observed in DS individuals.
Method.
RNA samples were obtained from peripheral blood, and gene expression was quantified using the TaqMan® Array Plate Human Inflammation Kit, which facilitated the investigation into 92 inflammation-related genes and four reference genes using real-time polymerase chain reaction (qPCR).
Results.
Twenty genes showed differential expression in children with DS; 12 were overexpressed (PLA2G2D, CACNA1D, ALOX12, VCAM1, ICAM1, PLCD1, ADRB1, HTR3A, PDE4C, CASP1, PLA2G5, and PLCB4), and eight were underexpressed (LTA4H, BDKRB1, ADRB2, CD40LG, ITGAM, TNFRSF1B, ITGB1, and TBXAS1).
After statistically correcting for the false discovery rate, only the genes BDKRB1 and LTA4H showed differential expression, and both were underexpressed within the DS group.
Conclusion.
DS children showed differential expression of inflammation-related genes that were not located on chromosome 21 compared with children without DS.
The BDKRB1 and LTA4H genes may differentiate the case and control groups based on the inflammatory response, which plays an important role in DS pathogenesis.
American Psychological Association (APA)
Silva, Cláudia Regina Santos& Biselli-Périco, Joice Matos& Zampieri, Bruna Lancia& Silva, Wilson Araujo& de Souza, Jorge Estefano Santana& Bürger, Matheus Carvalho…[et al.]. 2016. Differential Expression of Inflammation-Related Genes in Children with Down Syndrome. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111186
Modern Language Association (MLA)
Silva, Cláudia Regina Santos…[et al.]. Differential Expression of Inflammation-Related Genes in Children with Down Syndrome. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111186
American Medical Association (AMA)
Silva, Cláudia Regina Santos& Biselli-Périco, Joice Matos& Zampieri, Bruna Lancia& Silva, Wilson Araujo& de Souza, Jorge Estefano Santana& Bürger, Matheus Carvalho…[et al.]. Differential Expression of Inflammation-Related Genes in Children with Down Syndrome. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111186