NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway
Joint Authors
Huang, Jianhua
Li, Li
Yuan, Weifeng
Zheng, Linxin
Guo, Zhenhui
Huang, Wenjie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of the present study is to investigate the protective effects and relevant mechanisms exerted by NEMO-binding domain peptide (NBD) against lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice.
The ALI model was induced by intratracheally administered atomized LPS (5 mg/kg) to BABL/c mice.
Half an hour before LPS administration, we treated the mice with increasing concentrations of intratracheally administered NBD or saline aerosol.
Two hours after LPS administration, each group of mice was sacrificed.
We observed that NBD pretreatment significantly attenuated LPS-induced lung histopathological injury in a dose-dependent manner.
Western blotting established that NBD pretreatment obviously attenuated LPS-induced IκB-α and NF-κBp65 activation and NOX1, NOX2, and NOX4 overexpression.
Furthermore, NBD pretreatment increased SOD and T-AOC activity and decreased MDA levels in lung tissue.
In addition, NBD also inhibited TNF-α and IL-1β secretion in BALF after LPS challenge.
In conclusion, NBD protects against LPS-induced ALI in mice.
American Psychological Association (APA)
Huang, Jianhua& Li, Li& Yuan, Weifeng& Zheng, Linxin& Guo, Zhenhui& Huang, Wenjie. 2016. NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111205
Modern Language Association (MLA)
Huang, Jianhua…[et al.]. NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111205
American Medical Association (AMA)
Huang, Jianhua& Li, Li& Yuan, Weifeng& Zheng, Linxin& Guo, Zhenhui& Huang, Wenjie. NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111205