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Epithelial Anion Transport as Modulator of Chemokine Signaling
Joint Authors
Schnúr, Andrea
Hegyi, Péter
Rousseau, Simon
Lukacs, Gergely L.
Veit, Guido
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-12
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The pivotal role of epithelial cells is to secrete and absorb ions and water in order to allow the formation of a luminal fluid compartment that is fundamental for the epithelial function as a barrier against environmental factors.
Importantly, epithelial cells also take part in the innate immune system.
As a first line of defense they detect pathogens and react by secreting and responding to chemokines and cytokines, thus aggravating immune responses or resolving inflammatory states.
Loss of epithelial anion transport is well documented in a variety of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, pancreatitis, and cholestatic liver disease.
Here we review the effect of aberrant anion secretion with focus on the release of inflammatory mediators by epithelial cells and discuss putative mechanisms linking these transport defects to the augmented epithelial release of chemokines and cytokines.
These mechanisms may contribute to the excessive and persistent inflammation in many respiratory and gastrointestinal diseases.
American Psychological Association (APA)
Schnúr, Andrea& Hegyi, Péter& Rousseau, Simon& Lukacs, Gergely L.& Veit, Guido. 2016. Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1111214
Modern Language Association (MLA)
Schnúr, Andrea…[et al.]. Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators of Inflammation No. 2016 (2016), pp.1-20.
https://search.emarefa.net/detail/BIM-1111214
American Medical Association (AMA)
Schnúr, Andrea& Hegyi, Péter& Rousseau, Simon& Lukacs, Gergely L.& Veit, Guido. Epithelial Anion Transport as Modulator of Chemokine Signaling. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1111214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111214