Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis
Joint Authors
Brzosko, Marek
Przepiera-Będzak, Hanna
Fischer, Katarzyna
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA).
Patients and Methods.
We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO.
We assessed extra-articular symptoms in all cases.
In 191 SpA patients, we measured serum interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-23 (IL-23), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF).
Results.
Patients with acute anterior uveitis (AAU) had higher VAS (P=0.0008), BADSDAI (P=0.0001), ASDAS-ESR (P=0.04), CRP (P=0.006), IL-6 (P=0.02), and IL-18 (P=0.03) levels.
Patients with inflammatory bowel disease (IBD) had higher VAS (P=0.03), CRP (P=0.0009), and IL-6 (P=0.0003) levels.
Patients with skin psoriasis had lower VAS (P=0.001) and BASDAI (P=0.00007) levels.
Patients with psoriatic onycholysis had lower VAS (P=0.006), BASDAI (P=0.00001), and CRP (P=0.02) and higher IL-23 (P=0.04) levels.
Patients with PPP had lower BASDAI (P=0.04) and higher ET-1 (P=0.001) levels.
Conclusions.
SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms.
In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP.
American Psychological Association (APA)
Przepiera-Będzak, Hanna& Fischer, Katarzyna& Brzosko, Marek. 2016. Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111215
Modern Language Association (MLA)
Przepiera-Będzak, Hanna…[et al.]. Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1111215
American Medical Association (AMA)
Przepiera-Będzak, Hanna& Fischer, Katarzyna& Brzosko, Marek. Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111215