Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis
Joint Authors
Pufe, T.
Stope, Matthias
Albrecht, Lea-Jessica
Tauber, Simone C.
Merres, Julika
Kress, Eugenia
Jansen, Sandra
Brandenburg, Lars-Ove
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus pneumoniae.
By entering the brain, host cells will be activated and proinflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are released.
The goal of the current study was to examine the interaction between IL-6 and TNFR1 as receptor for TNF-α and the innate immune response in vivo in a model of Streptococcus pneumoniae-induced meningitis.
For the experiments IL-6−/−, TNFR1−/−, and TNFR1-IL-6−/− KO mice were used.
Our results revealed higher mortality rates and bacterial burden after infection in TNFR1−/−, IL-6−/−, and TNFR1-IL-6−/− mice and a decreased immune response including lower neutrophil infiltration in the meninges of TNFR1−/− and TNFR1-IL-6−/− mice in contrast to IL-6−/− and wild type mice.
Furthermore, the increased mortality of TNFR1−/− and TNFR1-IL-6−/− mice correlated with decreased glial cell activation compared to IL-6−/− or wild type mice after pneumococcal meningitis.
Altogether, the results show the importance of TNFR1 and IL-6 in the regulation of the innate immune response.
The lack of TNFR1 and IL-6 results in higher mortality by weakened immune defence, whereas the lack of TNFR1 results in more severe impairment of the innate immune response than the lack of IL-6 alone.
American Psychological Association (APA)
Albrecht, Lea-Jessica& Tauber, Simone C.& Merres, Julika& Kress, Eugenia& Stope, Matthias& Jansen, Sandra…[et al.]. 2016. Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111220
Modern Language Association (MLA)
Albrecht, Lea-Jessica…[et al.]. Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111220
American Medical Association (AMA)
Albrecht, Lea-Jessica& Tauber, Simone C.& Merres, Julika& Kress, Eugenia& Stope, Matthias& Jansen, Sandra…[et al.]. Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111220