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Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations
Joint Authors
Spinelli, F. R.
Valesini, Guido
Truglia, Simona
Conti, Fabrizio
Ceccarelli, Fulvia
Miranda, Francesca
Bombardieri, Michele
Giannakakis, Konstantinos
Alessandri, Cristiano
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The study aimed at locating and quantifying Toll Like Receptor (TLR) 3, 7, 8, and 9 expression in kidney of patients with lupus nephritis (LN) and correlating them with clinicopathological features.
Methods.
Kidney sections from 26 LN patients and 4 controls were analyzed by immunohistochemistry using anti-human TLR3, TLR7, TLR8, and TLR9 polyclonal antibodies; the number of TLR-positive nuclei/mm2 was evaluated on digitalized images.
Results.
Compared to controls, LN showed a significantly higher amount of glomerular and tubulointerstitial TLR9 (p=0.003 and p=0.007), whole and tubulointerstitial TLR3 (p=0.026 and p=0.031), and a higher tubulointerstitial TLR7 (p=0.022).
TLR9 positively correlated with activity index (p=0.0063) and tubular TLR7 with chronicity index (p=0.026).
TLR9 positively correlated with Renal-SLEDAI (p=0.01).
Conclusions.
This is the first study quantifying kidney expressions of TLRs in LN patients; the results show an overexpression of TLR3, TLR7, and TLR9 and demonstrate a correlation with clinicopathological indices supporting a role of these mediators in the pathogenesis of LN.
American Psychological Association (APA)
Conti, Fabrizio& Spinelli, F. R.& Truglia, Simona& Miranda, Francesca& Alessandri, Cristiano& Ceccarelli, Fulvia…[et al.]. 2016. Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111222
Modern Language Association (MLA)
Conti, Fabrizio…[et al.]. Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1111222
American Medical Association (AMA)
Conti, Fabrizio& Spinelli, F. R.& Truglia, Simona& Miranda, Francesca& Alessandri, Cristiano& Ceccarelli, Fulvia…[et al.]. Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111222