Manipulation of P2X Receptor Activities by Light Stimulation
Author
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
P2X receptors are involved in amplification of inflammatory responses in peripheral nociceptive fibers and in mediating pain-related signals to the CNS.
Control of P2X activation has significant importance in managing unwanted hypersensitive neuron responses.
To overcome the limitations of chemical ligand treatment, optical stimulation methods of optogenetics and photoswitching achieve efficient control of P2X activation while allowing specificity at the target site and convenient stimulation by light illumination.
There are many potential applications for photosensitive elements, such as improved uncaging methods, photoisomerizable ligands, photoswitches, and gold nanoparticles.
Each technique has both advantages and downsides, and techniques are selected according to the purpose of the application.
Technical advances not only provide novel approaches to manage inflammation or pain mediated by P2X receptors but also suggest a similar approach for controlling other ion channels.
American Psychological Association (APA)
Kim, SangSeong. 2016. Manipulation of P2X Receptor Activities by Light Stimulation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1111223
Modern Language Association (MLA)
Kim, SangSeong. Manipulation of P2X Receptor Activities by Light Stimulation. Mediators of Inflammation No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1111223
American Medical Association (AMA)
Kim, SangSeong. Manipulation of P2X Receptor Activities by Light Stimulation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1111223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111223