Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells
Joint Authors
Lu, Cheng
Zhao, Hongyan
Qiu, Qi
Xu, Huihui
Wang, Gui
Huang, Jing
Guo, Minghui
Guo, Baosheng
Xiao, Cheng
Tan, Yong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Triptolide, a purified component of Tripterygiumwilfordii Hook F, has been shown to have immunosuppressive and anti-inflammatory properties in rheumatoid arthritis (RA).
Although triptolide has demonstrated that it could suppress bone destruction in collagen-induced mice, its therapeutic mechanism remains unclear.
Many studies have investigated the effect of triptolide on Tregs and Tregs-related cytokine involved in RA.
Additionally, previous studies have implied that Tregs inhibit osteoclast differentiation and bone resorption.
Thus, in this study we aimed to explore the regulatory mechanism by which triptolide influences the Treg-mediated production of IL-10 and TGF- β1 to affect osteoclast differentiation and bone resorption.
In cocultures system of Tregs and mouse bone marrow macrophages (BMMs), Tregs inhibited the differentiation of osteoclasts and reduced the resorbed areas significantly and the production of both IL-10 and TGF- β1 was upregulated.
When the coculture systems were pretreated with triptolide, they produced higher levels of IL-10 and TGF- β1.
Our data indicate that triptolide enhances the suppressive effects of Tregs on osteoclast differentiation and bone resorption by enhancing the secretion of IL-10 and TGF- β1.
Tregs are most likely involved in the triptolide-mediated regulation of bone metabolism and may provide a potential therapeutic target for the treatment of inflammatory bone destruction.
American Psychological Association (APA)
Xu, Huihui& Zhao, Hongyan& Lu, Cheng& Qiu, Qi& Wang, Gui& Huang, Jing…[et al.]. 2016. Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111240
Modern Language Association (MLA)
Xu, Huihui…[et al.]. Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111240
American Medical Association (AMA)
Xu, Huihui& Zhao, Hongyan& Lu, Cheng& Qiu, Qi& Wang, Gui& Huang, Jing…[et al.]. Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111240