![](/images/graphics-bg.png)
A H2S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice
Joint Authors
Yang, Tianxin
Sun, Ying
Zhang, Aihua
Jia, Zhanjun
Liu, Mi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Accumulating evidence demonstrated that hydrogen sulfide (H2S) is highly involved in inflammation, oxidative stress, and apoptosis and contributes to the pathogenesis of kidney diseases.
However, the role of H2S in cisplatin nephrotoxicity is still debatable.
Here we investigated the effect of GYY4137, a novel slow-releasing H2S donor, on cisplatin nephrotoxicity in mice.
Male C57BL/6 mice were pretreated with GYY4137 for 72 h prior to cisplatin injection.
After cisplatin treatment for 72 h, mice developed obvious renal dysfunction and kidney injury as evidenced by elevated blood urea nitrogen (BUN) and histological damage.
Consistently, these mice also showed increased proinflammatory cytokines such as TNF-α, IL-6, and IL-1β in circulation and/or kidney tissues.
Meanwhile, circulating thiobarbituric aid-reactive substances (TBARS) and renal apoptotic indices including caspase-3, Bak, and Bax were all elevated.
However, application of GYY4137 further aggravated renal dysfunction and kidney structural injury in line with promoted inflammation, oxidative stress, and apoptotic response following cisplatin treatment.
Taken together, our results suggested that GYY4137 exacerbated cisplatin-induced nephrotoxicity in mice possibly through promoting inflammation, oxidative stress, and apoptotic response.
American Psychological Association (APA)
Liu, Mi& Jia, Zhanjun& Sun, Ying& Zhang, Aihua& Yang, Tianxin. 2016. A H2S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111244
Modern Language Association (MLA)
Liu, Mi…[et al.]. A H2S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111244
American Medical Association (AMA)
Liu, Mi& Jia, Zhanjun& Sun, Ying& Zhang, Aihua& Yang, Tianxin. A H2S Donor GYY4137 Exacerbates Cisplatin-Induced Nephrotoxicity in Mice. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111244