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Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease
Joint Authors
Gong, Fangchen
Wu, Jin
Zhou, Ping
Zhang, Mengyao
Liu, Jingning
Liu, Ying
Lu, Xiang
Liu, Zhengxia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation.
The role of Th17 and its related cytokines in T2DM and CAD is unclear.
Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-27) in T2DM, CAD, and T2DM-CAD comorbidity patients.
IL-22 was found to be elevated in all three conditions.
Elevated serum IL-22 was independently associated with the incidence of T2DM and CAD.
Conversely, IL-22 was found to protect endothelial cells from glucose- and lysophosphatidylcholine- (LPC-) induced injury, and IL-22R1 expression on endothelial cells was increased upon treatment with high glucose and LPC.
Blocking of IL-22R1 with IL-22R1 antibody diminished the protective role of IL-22.
Our results suggest that IL-22 functions as a double-edged sword in T2DM and CAD and that IL-22 may be used in the treatment of chronic inflammatory diseases such as T2DM and CAD.
American Psychological Association (APA)
Gong, Fangchen& Wu, Jin& Zhou, Ping& Zhang, Mengyao& Liu, Jingning& Liu, Ying…[et al.]. 2016. Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111250
Modern Language Association (MLA)
Gong, Fangchen…[et al.]. Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111250
American Medical Association (AMA)
Gong, Fangchen& Wu, Jin& Zhou, Ping& Zhang, Mengyao& Liu, Jingning& Liu, Ying…[et al.]. Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111250