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Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice
Joint Authors
Ledesma-Soto, Yadira
Juárez, Imelda
Rodriguez-Canales, Mario
Jimenez-Rivas, Ruben
Canales-Martinez, Maria Margarita
Garcia-Lopez, Ana Judith
Rivera-Yañez, Nelly
Nieto-Yañez, Oscar
Rodriguez-Monroy, Marco Aurelio
Sánchez-Torres, Luvia Enid
Terrazas, Luis I.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Amphipterygium adstringens is an endemic species in Mexico commonly known as “cuachalalate.” Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark.
We investigated the effects of alcoholic extract of A.
adstringens (AaEE) in DSS-induced colitis in mice.
The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days.
We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa.
AaEE significantly reduced the inflammation of colon and significantly increased SOD and GPx activities.
AaEE also significantly decreased TNF-α, IFN-γ, and IL-1β cytokine levels compared to DSS-treated mice and reduced both infiltration of inflammatory cells and the mucosal damage in colon.
The results suggested the protective potential of AaEE in DSS-induced colitis and this might be attributed to its phytochemicals compounds that have been found to induce a wide spectrum of activities such as reduction in oxidative stress, suppression of inflammation, modulating numerous signal transduction pathways, and induction of apoptosis.
The findings of this study suggest that AaEE has substantial potential for the treatment of inflammatory colitis.
American Psychological Association (APA)
Rodriguez-Canales, Mario& Jimenez-Rivas, Ruben& Canales-Martinez, Maria Margarita& Garcia-Lopez, Ana Judith& Rivera-Yañez, Nelly& Nieto-Yañez, Oscar…[et al.]. 2016. Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111263
Modern Language Association (MLA)
Rodriguez-Canales, Mario…[et al.]. Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111263
American Medical Association (AMA)
Rodriguez-Canales, Mario& Jimenez-Rivas, Ruben& Canales-Martinez, Maria Margarita& Garcia-Lopez, Ana Judith& Rivera-Yañez, Nelly& Nieto-Yañez, Oscar…[et al.]. Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111263
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111263