Neuroinvasion and Inflammation in Viral Central Nervous System Infections
Joint Authors
Dahm, Tobias
Rudolph, Henriette
Tenenbaum, Tobias
Schwerk, Christian
Schroten, Horst
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-25
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Neurotropic viruses can cause devastating central nervous system (CNS) infections, especially in young children and the elderly.
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) have been described as relevant sites of entry for specific viruses as well as for leukocytes, which are recruited during the proinflammatory response in the course of CNS infection.
In this review, we illustrate examples of established brain barrier models, in which the specific reaction patterns of different viral families can be analyzed.
Furthermore, we highlight the pathogen specific array of cytokines and chemokines involved in immunological responses in viral CNS infections.
We discuss in detail the link between specific cytokines and chemokines and leukocyte migration profiles.
The thorough understanding of the complex and interrelated inflammatory mechanisms as well as identifying universal mediators promoting CNS inflammation is essential for the development of new diagnostic and treatment strategies.
American Psychological Association (APA)
Dahm, Tobias& Rudolph, Henriette& Schwerk, Christian& Schroten, Horst& Tenenbaum, Tobias. 2016. Neuroinvasion and Inflammation in Viral Central Nervous System Infections. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1111264
Modern Language Association (MLA)
Dahm, Tobias…[et al.]. Neuroinvasion and Inflammation in Viral Central Nervous System Infections. Mediators of Inflammation No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1111264
American Medical Association (AMA)
Dahm, Tobias& Rudolph, Henriette& Schwerk, Christian& Schroten, Horst& Tenenbaum, Tobias. Neuroinvasion and Inflammation in Viral Central Nervous System Infections. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1111264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111264