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Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome
Joint Authors
Zuñiga-Muñoz, Alejandra
Guarner Lans, Verónica
Pérez-Torres, Israel
Soto, María Elena
Duran-Hernández, Erendira Janet
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Marfan syndrome (MFS) is associated with progressive aortic dilatation, endothelial dysfunction, and oxidative stress that contribute to the early acute dissection of the vessel and can end up in rupture of the aorta and sudden death.
Many studies have described that the organic acids from Hibiscus sabdariffa Linne (HSL) calyces increase cellular antioxidant capacity and decrease oxidative stress.
Here we evaluate if the antioxidant properties of HSL infusion improve oxidative stress in MFS patients.
Activities of extra cellular super oxide dismutase (ECSOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), glutathione reductase (GSSG-R), glutathione (GSH), lipid peroxidation (LPO) index, total antioxidant capacity (TAC), and ascorbic acid were determined in plasma from MFS patients.
Values before and after 3 months of the treatment with 2% HSL infusion were compared in control and MFS subjects.
After treatment, there was a significant decrease in ECSOD (p=0.03), EGPx (p=0.04), GST (p=0.03), GSH (p=0.01), and TAC and ascorbic acid (p=0.02) but GSSG-R activity (p=0.04) and LPO (p=0.02) were increased in MFS patients in comparison to patients receiving the HSL treatment and C subjects.
Therefore, the infusion of HSL calyces has antioxidant properties that allow an increase in antioxidant capacity of both the enzymatic and nonenzymatic systems, in the plasma of the MSF patients.
American Psychological Association (APA)
Soto, María Elena& Zuñiga-Muñoz, Alejandra& Guarner Lans, Verónica& Duran-Hernández, Erendira Janet& Pérez-Torres, Israel. 2016. Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111267
Modern Language Association (MLA)
Soto, María Elena…[et al.]. Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1111267
American Medical Association (AMA)
Soto, María Elena& Zuñiga-Muñoz, Alejandra& Guarner Lans, Verónica& Duran-Hernández, Erendira Janet& Pérez-Torres, Israel. Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1111267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111267