Inhibitory Effect of Loranthus parasiticus on IgE-Mediated Allergic Responses in RBL-2H3 Cells
Joint Authors
Ma, Jin Yeul
Yang, Ju-Hye
Yoo, Jae-Myung
Kim, Young Soo
Cho, Won-Kyung
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The mistletoe Loranthus parasiticus has been used as a compound for traditional medicine in Northeast Asia for a long time and is known to possess neuroprotective action.
Nonetheless, the effect of Loranthus parasiticus on allergic responses remains unknown.
In the present study, we evaluated whether the water extract of Loranthus parasiticus (LPE) could inhibit IgE-mediated allergic responses in RBL-2H3 cells.
LPE inhibited the release of β-hexosaminidase (IC50, 184.5 μg/mL) and the formation of tumor necrosis factor-α (IC50, 84.27 μg/mL), interleukin-4 (IC50, 93.43 μg/mL), prostaglandin E2 (IC50, 84.10 μg/mL), prostaglandin D2, and leukotriene C4 (IC50, 43.27 μg/mL) in a concentration-dependent manner.
Moreover, LPE inhibited phosphorylation of Syk, PLCγ1/2, PKCδ, ERK, JNK, p38, and Akt.
In the late phase, LPE decreased 5-lipoxygenase phosphorylation and COX-2 expression but not cPLA2 phosphorylation.
Additionally, LPE included total phenolic compounds (10.72 mg/g dry weight) and total flavonoids (56.20 mg/g dry weight).
These results suggest that the phenolic compounds or flavonoids contained in LPE may be associated with antiallergic activity.
The phenolic compounds and flavonoids in LPE are antiallergic phytochemicals capable of inhibiting the activation of the FcεRI signaling cascade in mast cells.
Such effects may provide further information for the development of a phytomedicine for allergic diseases.
American Psychological Association (APA)
Yoo, Jae-Myung& Yang, Ju-Hye& Kim, Young Soo& Cho, Won-Kyung& Ma, Jin Yeul. 2016. Inhibitory Effect of Loranthus parasiticus on IgE-Mediated Allergic Responses in RBL-2H3 Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111272
Modern Language Association (MLA)
Yoo, Jae-Myung…[et al.]. Inhibitory Effect of Loranthus parasiticus on IgE-Mediated Allergic Responses in RBL-2H3 Cells. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111272
American Medical Association (AMA)
Yoo, Jae-Myung& Yang, Ju-Hye& Kim, Young Soo& Cho, Won-Kyung& Ma, Jin Yeul. Inhibitory Effect of Loranthus parasiticus on IgE-Mediated Allergic Responses in RBL-2H3 Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111272