![](/images/graphics-bg.png)
The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway
Joint Authors
de Menezes, Liliana Borges
Celes, Mara Rúbia Nunes
Soave, Danilo Figueiredo
Miguel, Marina Pacheco
Tomé, Fernanda Dias
Nagib, Patrícia Resende Alo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Since 2000, written with elegance and accuracy, Hanahan and Weinberg have proposed six major hallmarks of cancer and, together, they provide great advances to the understanding of tumoral biology.
Our knowledge about tumor behavior has improved and the investigators have now recognized that inflammatory microenvironment may be a new feature for the tumor entities.
Macrophages are considered as an important component of tumoral microenvironment.
Biologically, two forms of activated macrophages can be observed: classically activated macrophages (M1) and alternative activated macrophages (M2).
Despite the canonical pathways that control this puzzle of macrophages polarization, recently, mTOR signaling pathway has been implicated as an important piece in determining the metabolic and functional differentiation of M1 and M2 profiles.
Currently, it is believed that macrophages related to tumoral microenvironment present an “M2-like” feature promoting an immunosuppressive microenvironment enhancing tumoral angiogenesis, growth, and metastasis.
In the present review we discuss the role of macrophages in the tumor microenvironment and the role of mTOR pathway in M1 and M2 differentiation.
We also discuss the recent findings in M1 and M2 polarization as a possible target in the cancer therapy.
American Psychological Association (APA)
Soave, Danilo Figueiredo& Miguel, Marina Pacheco& Tomé, Fernanda Dias& de Menezes, Liliana Borges& Nagib, Patrícia Resende Alo& Celes, Mara Rúbia Nunes. 2016. The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111276
Modern Language Association (MLA)
Soave, Danilo Figueiredo…[et al.]. The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1111276
American Medical Association (AMA)
Soave, Danilo Figueiredo& Miguel, Marina Pacheco& Tomé, Fernanda Dias& de Menezes, Liliana Borges& Nagib, Patrícia Resende Alo& Celes, Mara Rúbia Nunes. The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111276